Nausheen has been in the Government Service for 36 years and retired as a Federal Secretary in April 2021. She held many key positions in the Federal Government including the Chairperson of the Federal Board of Revenue, also being the first female to finalize the Federal Budget 2021. She spent majority of her time in the Inland Revenue Services and held key positions in the field formation and at FBR headquarters including Member, Administration, Audit and Information Technology. She played a pivotal role in improving and formulating the Audit, IT along with external and internal Communication Policies. She has also garnered vast experience of working with international agencies including IMF, World Bank, OECD, DIFD and HMRC. Earlier, she has been the Chief Commissioner and Commissioner of largest tax jurisdictions of Pakistan i.e. Large Taxpayers Unit, Karachi. Nausheen being part of the policy team of FBR has evaluated the businesses from tax revenue perspective including reviewing the operational and financial business models of taxpayers. She was the key player which repivoted the tax jurisdictions and carved out the Large Taxpayers Unit and has served there for more than a decade, was also the first Chief Commissioner of second Large Taxpayers Unit of Karachi.

She is a certified director from Pakistan Institute of Corporate Governance and is representing Government of Pakistan on many important boards including, Pakistan Media Regulatory Authority, National Council of Arts, Academy of Letters etc. Nausheen is part of non-profit organizations including Parveen Shakir Foundation and has been an advocate of Women Empowerment and Diversity. To ensure advancement of women empowerment, she regularly mentors working women and fresh graduates.